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Recombinant Human IL-21 Protein

Recombinant Human IL-21 Protein
Recombinant Human IL-21 Protein
  • Stock: In Stock
  • Model: GMP-TL509
$427.00

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IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include:inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4;and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally,IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 exerts its effect through binding to a specific type I cytokine receptor,IL-21R,which also contains the γ chain (γc) found in other cytokine receptors, including IL-2,IL-4,IL-7,IL-9 and IL-15.The IL-21/IL-21R interaction triggers a cascade of events,which includes activation of the tyrosine kinases JAK1 and JAK3,followed by activation of the transcription factors STAT1 and STAT3.


Cytokines
Expression Host CHO cells
Synonym CVID11, IL-21, Za11
Protein Sequence A DNA sequence encoding the extracellular domain of human IL-21(Q9HBE4-1: Q29-S162) was expressed with the C-terminal fused Fc region of human IgG1.
Molecular Mass The recombinant human IL-21 predicts a molecular mass of 41.9kD.
QC Testing Purity > 95 % as determined by SDS-PAGE.
Endotoxin < 0.01 EU per μg of the protein as determined by the LAL method.
Activity Measured by its ability of inducing human natural killer lymphoma NK-92 cells to secrete interferon-γ. The expected ED₅₀ is ≤ 50 ng/mL
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.
Stability Lyophilized preparation can be stored at -20 ℃. 6 months at -20℃ under sterile conditions after reconstitution. 12 months at -80℃ under sterile conditions after reconstitution.
Storage Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL. Avoid repeated freeze-thaw cycles.
Thumb File information
GMP-TL509_SDS.pdf 162.53KB 84
GMP-TL509_Product Sheet.pdf 84.22KB 102

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