Anti-Human CD137 mAb
- Stock: In Stock
- Model: GMP-TL778
Available Options
4-1BB,
also known as CD137, is an inducible cell surface receptor and one member of
tumor necrosis factor receptor (tumor
necrosis factor receptor,
TNFR) superfamily. CD137
is encoded by
the tumor necrosis
factor receptor superfamily member
9 (TNFRSF9) gene
and widely expressed
on the surface
of activated T cells
and NK cells.
Its ligand, CD137L, also a TNFSF member, is an inducible costimulatory
receptor expressed by activated CD4 + and CD8 + T cells, NKT, NK cells, DC,
macrophages, eosinophils, neutrophils and mast cells, especially on CD8 + T
cells. CD137 / CD137L mediate immune responses by transmitting activation,
proliferation, or apoptotic signals between immune cells. The activation of CD137 can stimulate NK
cell and T cell proliferation and generate anti-tumor activity, which induces durable
memory responses. 4-1BB mAb can activate 4-1BB to recruit TNFR related factors
TRAF1 and TRAF2. Then, TRAF1 and TRAF2 form a heterotrimer, which strengthens
signal transduction through c-Jun N terminal kinase (JNK) or extracellular
signal-regulated kinase (ERK) pathway. This heterotrimer can stimulate the
proliferation of T cells and antigen-presenting
cells, improve anti-tumor
immune response of
the body and
secrete cytokines through
the transcription of NF-κB.
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